Cayuga Lake Scenic Byway is centrally located in New York State, within 2 hours driving time from Niagara Falls & Albany and 4 hours from New York City and Toronto.

From I-90 NYS Thruway
Exit 40: South on Route 34, West on Route 5 & 20, then Rt. 90 South
Exit 41:  South on 414, East on 318, then East on 5&20 to 89 South (West side), or Route 90 South (East side)

From I-86
Route 13 North to Ithaca; to Route 89 North (West side)
or Route 34 (East side)

From I-81
Exit 11 onto Route 13 South to Ithaca; to Route 89 North (West side)
or Route 34 (East side)